Research Integrity and Peer Review

Table 5 Risk of bias and applicability assessment of diagnostic test accuracy studies using the QUADAS-2 tool

From: An evaluation of the preprints produced at the beginning of the 2022 mpox public health emergency

		Risk of bias^a				Applicability concerns
Study	Publication status	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Albin [71, 72]	Preprint	Low	Low	Low	Low	Low	Low	Low
Albin [71, 72]	Published	Low	Low	Low	Low	Low	Low	Low
Allan-Blitz [60, 61]	Preprint	Unclear	Unclear	Unclear	Unclear	Unclear	Low	Low
Allan-Blitz [60, 61]	Published	Low	Unclear	Unclear	Unclear	Low	Low	Low
La Rosa [64, 65]	Preprint	Low	Low	Low	Low	Low	Low	Low
La Rosa [64, 65]	Published	Low	Low	Low	Low	Low	Low	Low
Nörz [73, 74]	Preprint	High	Unclear	Unclear	Low	Low	Low	Low
Nörz [73, 74]	Published	Unclear	Low	Unclear	Low	Low	Low	Unclear
Wang [66, 67]	Preprint	High	Unclear	Low	Low	Low	Low	Low
Wang [66, 67]	Published	Unclear	Unclear	Low	Low	Low	Low	Low
Wu^b [70]	Published	High	Unclear	Unclear	Low	High	Unclear	Unclear
Ali [59]	Unpublished	High	Low	Unclear	Unclear	Unclear	Low	Unclear
Bhadra [62]	Unpublished	Low	Unclear	Low	Low	High	Low	High
Islam [63]	Unpublished	High	Unclear	Low	Unclear	Unclear	Unclear	Low
Wawina-Bokalanga [68]	Unpublished	Low	Unclear	Unclear	Low	Low	Low	Low
Wolfe [69]	Unpublished	Low	Low	Low	Low	Low	Low	Low

^aLow indicates low risk of bias, high indicates high risk of bias, and unclear indicates lack of reporting. Bolding indicates a change in quality for that domain
^bOnly the published version was classified as a diagnostic test accuracy study and evaluated for quality; the preprint was classified as a bioinformatic analysis [62]

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ISSN: 2058-8615

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